Your signs and symptoms, if any, will depend on the affected part of your body. The cause of Paget's disease of bone is unknown. Scientists suspect a combination of environmental and genetic factors contribute to the disease. Several genes appear to be linked to getting the disease. Some scientists believe Paget's disease of bone is related to a viral infection in your bone cells, but this theory is controversial. In most cases, Paget's disease of bone progresses slowly.
The disease can be managed effectively in nearly all people. Possible complications include:. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version. Bones muscles and joints. Home Bones muscles and joints.
Paget's disease of bone. Actions for this page Listen Print. Summary Read the full fact sheet. On this page. Depending on how severe your condition is, symptoms may include: pain and aching in your bones affected bones may become deformed or misshapen affected bones can feel warmer than the rest of your body if your skull is affected you may experience problems with hearing, headaches, vertigo or tinnitus.
However, in some cases, complications can arise including: osteoarthritis — in joints close to bones affected by Paget's disease, the cushioning cartilage on the ends of the bones can break down, causing pain and stiffness broken bones — the new bone growth is weak and fragile, and is more susceptible to fracture than healthy bone hearing loss — caused by pressure on nerves in the ear numbness or tingling in the spine — caused by pinched nerves in the spinal cord heart disease — due to the increased number of blood vessels in the affected bones, the heart has to work harder.
This is rare, but it can cause symptoms such as fatigue, weakness, abdominal pain, constipation, loss of appetite. They help the body control the bone-building process to stimulate more normal bone growth pain relieving medications analgesics and non-steroidal anti-inflammatory drugs NSAIDs — are used to provide temporary pain relief calcium and vitamin D — are both important for bone health. You can get calcium through your diet and vitamin D through safe exposure to sunlight.
Or talk with your doctor about whether you need to consider taking supplements. Examples include: a walking stick to reduce the weight placed through affected bones braces to correct position foot orthotics to support and correct abnormal foot position or motion enjoy a healthy well-balanced diet — this can help you reach and maintain a healthy weight and reduce your risk of other health problems. Symptoms of bone cancer are similar to those of Paget's disease of bone.
They can include:. Osteosarcoma is a very serious type of cancer that can spread to other parts of the body quickly. But if it's caught early enough, it may be possible to cure it by removing the affected bone. Page last reviewed: 31 October Next review due: 31 October Paget's disease of bone can sometimes lead to further problems. Broken bones Bones affected by Paget's disease of bone tend to be more fragile than normal bone and are more likely to break fracture — even after a relatively minor injury.
Signs of a fracture include: sudden, severe pain swelling or tenderness around the injured area bleeding, if the bone has damaged the tissue and skin It's not clear whether bisphosphonate medication helps prevent or treat fractures. Bone deformities It's common for Paget's disease of bone to affect the appearance of affected bones.
J Clin Endocrinol Metab 99 12 , PMID: The disease Several other mutations associated with Paget disease have been identified, many affecting the RANK receptor activator of nuclear factor kappa-B signaling pathway that is critical for osteoclast generation and activity. A viral etiology, such as measles, has been proposed because nuclear inclusions in diseased osteoclasts that are similar to those seen in paramyxovirus-infected cells have been seen on electron microscopy.
Although a viral cause has not been established, it is hypothesized that in genetically predisposed patients an as yet unidentified virus triggers abnormal osteoclast activity. Am J Hum Genet —, Endocr Rev 34 4 , Epub Apr Any bone can be involved in Paget disease.
The bones most commonly affected are the pelvis, femur, and skull. Other less commonly involved bones are the tibia, vertebrae, clavicle, and humerus. Bone turnover is accelerated at involved sites.
Pagetic lesions are metabolically active and highly vascular. Excessively active osteoclasts are often large and contain many nuclei. Osteoblastic repair is also hyperactive, causing coarsely woven, thickened lamellae and trabeculae. This abnormal structure weakens the bone, despite bone enlargement and areas of bone sclerosis. Osteoarthritis Osteoarthritis OA Osteoarthritis is a chronic arthropathy characterized by disruption and potential loss of joint cartilage along with other joint changes, including bone hypertrophy osteophyte formation.
Pathologic fracture is also common due to focal areas of weakened bone. Overgrown bone may compress nerves and other structures passing through small foramina. Spinal stenosis Lumbar Spinal Stenosis Lumbar spinal stenosis is narrowing of the lumbar spinal canal compresses the nerve rootlets and nerve roots in the cauda equina before their exit from the foramina.
It causes positional back Diagnosis is by MRI. Treatment is directed at relieving compression. See also Rare complications include transformation to osteosarcoma Osteosarcoma osteogenic sarcoma Primary bone tumors are much less common than metastatic bone tumors, particularly in adults.
Primary bone tumors include multiple myeloma, osteosarcoma, adamantinoma, chondrosarcoma, chordoma Principal causes include hyperparathyroidism, vitamin
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